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The 17q12-21 locus harboring ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) and Gasdermin B (GSDMB) genes exhibits one of the most significant and replicated associations with asthma [MIM:600807] (Stein et al.,2018).Several studies explored the complex interactions between SNPs,gene expression and epigenetic modifications at this locus,primarily focusing on the levels of expressed ORMDL3 and GSDMB (Stein et al.,2018).Given that DNA methylation and gene expression signals are cell-type specific (Reinius et al.,2012),isolated materials such as lymphocytes from blood and,to a lesser extent,bronchial epithelial cells from biopsies of bronchi or bronchoalveolar lavages have been used in a number of studies to investigate such interactions (Stein et al.,2018).None of these studies has taken advantage of next generation sequencing,imputed GWAS data and methylation profile of immune isolated cells from blood of asthmatic and non-asthmatic individuals to analyze the 17q12-21 locus (Stein et al.,2018).In this study,taking benefits from the above-mentioned technologies,we identified associations between genetic variants,DNA methylation levels and GSDMA expression counts in na(i)ve CD4+ T cells isolated from asthmatic and non-asthmatic individuals (see www.jacionline.org,Supplementary data for detailed methodology).