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HNS(浓的环烷溶剂)的主要组分有环烷烃(环戊烷、环己烷和双环烷烃)占69.9%,正构和异构石蜡29%,芳香族溶剂低于1.1%。大鼠吸入 HNS 4小时,其 LG_(50)为5,300(4,400-6,700)mg/M~3。按规定的统一实验程序和指标[注],大鼠吸入 HNS 浓度4,600mg/M~3,狗吸入浓度3,800mg/M~3,6小时无明显不适症状。吸入浓度5,500mg/M~3,每天6小时,每周5天,13周后,75%大鼠的肾小管上皮有变性肿胀,伴有染成浅红色均匀的胞浆内凝固物,而在2,100或610mg/M~3的浓度与对照组比无显著差异。
The main components of HNS (concentrated naphthenic solvent) are naphthenes (cyclopentane, cyclohexane and bicycloalkane) accounting for 69.9%, normal and paraffin waxes 29%, and aromatic solvents less than 1.1%. Rats inhaled HNS for 4 hours with an LG_ (50) of 5,300 (4,400-6,700) mg / M ~ 3. According to the provisions of the unified experimental procedures and indicators [Note], rats inhaled HNS concentration 4,600mg / M ~ 3, the dog inhalation concentration 3,800mg / M ~ 3,6 hours without obvious symptoms. Inhalation concentration of 5,500mg / M ~ 3, 6 hours a day, 5 days a week, after 13 weeks, 75% of rat renal tubular epithelial degeneration and swelling, accompanied by stained light red uniform cytoplasmic coagulation, The concentration of 2, 100 or 610mg / M ~ 3 had no significant difference with the control group.