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目的:探讨氯丙嗪对一氧化碳中毒致死时间延长现象。方法:采用甲酸和浓硫酸制备一氧化碳,统计同一锥形瓶中两只已经过不同药物处理后小鼠死亡时间。结果:用氯丙嗪后小鼠自主活动明显减少。用药后第2天、3天动物存活时间延长与对照组比没有差异。第4天有显著性差异。第5天、第6天存活时间有延长,但没有显著差异。结论:一定剂量的氯丙嗪经过体内代谢后,可以延长小鼠对一氧化碳中毒致死时间。
Objective: To investigate the prolonged exposure of chlorpromazine to carbon monoxide poisoning. Methods: Carbon monoxide was prepared from formic acid and concentrated sulfuric acid. The death time of two mice in the same conical flask after different drug treatment was counted. Results: After chlorpromazine significantly reduced spontaneous activity in mice. On the second day and the third day after treatment, there was no difference in the survival time of the animals compared with the control group. There was significant difference on the 4th day. On day 5, there was an increase in survival on day 6, but no significant difference. Conclusion: A certain dose of chlorpromazine can prolong the lethal time of carbon monoxide poisoning in mice.