论文部分内容阅读
以ELISA法测定68例矽肺患者(壹期35例、贰期21例、叁期12例)支气管肺泡灌洗液(BALF)中新喋呤(Npt)和IL-12的含量,随机选取20例工龄工种相似但未确诊矽肺的患者作为对照。矽肺各期BALF中Npt水平均高于对照组(P<0.01);贰期组高于壹期组、低于叁期组(P<0.05)。BALF中IL-12水平矽肺各组均高于对照组(P<0.01);贰、叁期组均高于壹期组(P<0.01),叁期组低于贰期组(P>0.05)。随着接尘工龄的增加IL-12与Npt水平呈下降趋势,二者可能具有协调作用并呈正相关。联合监测矽肺患者BALF中Npt和IL-12的浓度对矽肺的早期诊断具有一定的参考价值。
The contents of neptin (Npt) and IL-12 in bronchoalveolar lavage fluid (BALF) of 68 patients with silicosis (35 cases in one stage, 21 cases in stage II and 12 cases in stage II) were determined by ELISA. Twenty Patients of similar length of service but not diagnosed with silicosis served as controls. The level of Npt in BALF of silicosis was higher than that of the control group (P <0.01). The second stage group was higher than the first stage group and lower than the third stage group (P <0.05). The level of IL-12 in BALF was higher in the silicosis group than in the control group (P <0.01), and in the second and third groups were significantly higher than those in the first group (P <0.01) . The IL-12 and Npt levels showed a decreasing trend with the increase of the serviceman’s age, which may have a coordinative effect and a positive correlation. The combined monitoring of the concentration of Npt and IL-12 in BALF in patients with silicosis may be of some value in the early diagnosis of silicosis.