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目的系统评价中国人群转化生长因子(TGF)-β1基因T869C多态性与原发性高血压的关系。方法检索中文及外文数据库,收集2015年10月前发表的有关中国人群TGF-β1基因T869C多态性与原发性高血压关系的病例-对照研究的文献,数据进行Meta分析。结果共纳入7篇文献,2882例研究对象,病例组1560例,对照组1322例。TGF-β1基因T869C位点的基因型Meta分析结果,差异有统计学意义(P<0.01)。敏感性分析显示结果稳定。结论TGF-β1基因T869C多态性与原发性高血压有关联。
Objective To systematically evaluate the relationship between T869C polymorphism of transforming growth factor-β1 gene and essential hypertension in Chinese population. Methods The Chinese and foreign databases were searched and the data of case-control study on the relationship between T869C polymorphism of TGF-β1 gene and essential hypertension published in China before October 2015 were collected and analyzed by Meta-analysis. Results A total of 7 articles were included, 2882 subjects, 1560 cases and 1322 cases of control group. Genotype Meta analysis of TGF-β1 gene T869C showed significant difference (P <0.01). Sensitivity analysis showed stable results. Conclusion T869C polymorphism of TGF-β1 gene is associated with essential hypertension.