论文部分内容阅读
目的观察灵芝三萜类化合物(GLT)对拟阿尔茨海默病(AD)的衰老模型小鼠的学习记忆能力和脑组织谷氨酸(Glu)含量的影响,探讨GLT的作用机制。方法 5%D-半乳糖(D-gal)皮下注射建立衰老小鼠模型,同时灌胃给予GLT,正常对照组和模型组给予等体积生理盐水。用Morris水迷宫实验检测小鼠学习记忆能力,光化学法检测小鼠脑组织Glu含量。结果与正常对照组相比,模型组小鼠学习记忆能力降低,脑组织Glu含量增加。灌胃给予GLT后,小鼠上述变化明显改善,差异有显著统计学意义(P<0.05)。结论 GLT可改善D-gal衰老模型小鼠的学习记忆能力,其机制可能与GLT能够减少脑内Glu有关。
Objective To observe the effects of ganoderma lucidum triterpene (GLT) on learning and memory ability and glutamate (Glu) content in aging mice with Alzheimer’s disease (AD) and to explore the mechanism of action of GLT. Methods Aging mice model was established by subcutaneous injection of 5% D-galactose (D-gal), and GLT was administered intragastrically. The normal control group and model group were given equal volume of normal saline. Morris water maze test was used to detect the learning and memory abilities of mice, and the content of Glu in mouse brain was detected by photochemical method. Results Compared with the normal control group, the learning and memory abilities of the model group decreased and the content of Glu in the brain tissue increased. After gavage of GLT, the above changes in mice were significantly improved, the difference was statistically significant (P <0.05). Conclusion GLT can improve the learning and memory abilities of D-gal aging mice, and its mechanism may be related to the GLT can reduce the brain Glu.