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目的:优选小檗碱-β-环糊精包合物的最佳制备工艺。方法:采用正交试验法,以包合物的收率、包合率为评价指标,优选包合温度、包合时间、主客分子投料比,确定最佳包合条件。结果:饱和水溶液法制备小檗碱-β-环糊精包合物的最佳工艺为:温度为80℃,包合2 h,主客分子投料比为4∶1(g.g-1)。结论:优选的包合条件包合物收率及小檗碱包合率高,工艺切实可行。
Objective: To optimize the preparation of berberine-β-cyclodextrin inclusion compound. Methods: The optimum inclusion conditions were determined by orthogonal test, taking the inclusion compound yield and inclusion rate as evaluation indexes, including the inclusion temperature, inclusion time, feeding ratio of host and guest molecules. Results: The optimum conditions for the preparation of berberine-β-cyclodextrin inclusion by saturated aqueous solution were as follows: temperature 80 ℃, inclusion 2 h, feeding ratio 4: 1 (g.g-1). Conclusion: The inclusion rate of the inclusion compound and the high rate of inclusion of berberine, the process is feasible.