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四氯化碳系工业上常用之溶剂,医药上亦曾用为驱虫剂,在实验室中常用以诱发肝损伤。据文献①②记载动物于摄入四氯化碳后,肝、肾、心脏严重变性,中枢神经系统障碍,在此种情况下,显然有引起组织中的与蛋白质代谢有关的酶系,特别是氨基移换酶紊乱的可能,但在这方面的工作,文献上还少报导,且存在着矛盾,关于四氯化碳中毒时,血清氨基移换酶活力显较正常动物为高,业已肯定③④⑤。至于在此种条件下,肝中的氨基移换酶活力变化则尚不能确定,⑥将四氯化碳肌肉注射给予大鼠后一天杀死,发现动物肝
Carbon tetrachloride is a commonly used solvent in the industry. It has also been used as an insect repellent in medicine and is commonly used in the laboratory to induce liver damage. According to the literature12, after ingestion of carbon tetrachloride in animals, the liver, kidney, and heart are severely degenerated and the central nervous system is disordered. In this case, it is apparent that there are enzyme systems that cause protein metabolism in tissues, especially amino The possibility of shifting enzymes is disturbed, but in this work, there are few reports in the literature, and there are contradictions. When carbon tetrachloride is poisoned, serum aminotransferase activity is higher than that of normal animals, and it has been confirmed 345. As for the conditions under this condition, the aminotransferase activity in the liver has not been determined yet. 6 One day after intramuscular administration of carbon tetrachloride to rats, the animals were found to have liver disease.