日本科学家近日探明了从基因突变到大肠癌发病的全过程,这将对开发治疗大肠癌的新药有所帮助。日本东京大学分子细胞生物学研究所的秋山彻和川崎善博等发现,基因“APC”若发生突变,大肠上皮细胞的性质就会发生改变,更容易生成息肉,最终形成肿瘤。据日本《每日新闻》报道,秋山教授等人曾在两年前发现,许多大肠癌细胞中都存在突变的“APC”基因,这种基因产生的蛋白质“变异 APC”和细胞内另一种蛋白质“Asef”相结合,就会使“Asef”更具活性,细胞的性 Japanese scientists recently discovered the whole process from gene mutation to the development of colorectal cancer, which will help to develop new drugs for the treatment of colorectal cancer. Akiyama Toru and Kawasaki Shinobu, Institute of Molecular Cell Biology, University of Tokyo, Japan, found that if the gene “APC” is mutated, the properties of the large intestine epithelial cells will be changed, the polyps will be more likely to form and tumors will eventually form. According to Japan’s “Daily News” report, Professor Akiyama found that two years ago, many of the colorectal cancer cells have mutations in the “APC” gene, this gene produces the protein “mutation APC” and another intracellular The combination of protein “Asef” will make “Asef” more active and cellular