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中医学理论体系的灵魂是辨证论治,其特点是个性化、灵活化,因而适用于中医药类研究的动物模型应该既体现中医证候特征又能反映西医疾病属性,以全面和客观地评价中药的效应。本文结合2型糖尿病(T2DM)的中西医发病病因,筛选出较为理想的T2DM病证结合动物模型造模方法,即:诱导劳倦过度房事不节法、过量中药灌服法、长期激怒法、高脂饲养结合冠状动脉左前降支结扎术法,为中药新药的研发提供实验依据。
The soul of TCM theory system is syndrome differentiation, which is characterized by individuality and flexibility. Therefore, the animal model suitable for Chinese medicine research should not only reflect the TCM syndrome characteristics but also reflect the characteristics of Western medical diseases, so as to evaluate Chinese medicine comprehensively and objectively effect. In this paper, combined with the pathogenesis of type 2 diabetes mellitus (T2DM) of Chinese and Western medicine, screening more ideal combination of animal models of T2DM disease syndrome modeling methods: induction of excess labor overruns, excess traditional Chinese medicine irrigation method, long-term anger method, high Lipid feeding combined with left anterior descending coronary artery ligation method for the development of new drugs to provide experimental evidence.