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目的 :制备复方阿昔洛韦眼用凝胶 ,提供治疗单纯疱疹性角膜炎的药剂。方法 :制备并测定制剂中阿昔洛韦含量 ,进行体外试验、稳定性试验。结果 :制剂制备方法合理 ,测定阿昔洛韦含量 ,可排除凝胶基质的干扰 ;稳定性试验和体外释放试验表明本制剂质量稳定并有缓释作用 ;通过 6 0例单纯疱疹性角膜炎病人的临床应用 ,总有效率为 96 .7%。结论 :制剂质量稳定 ,对眼部无刺激 ,且持药时间长 ,是临床治疗单纯疱疹性角膜炎的较理想制剂
OBJECTIVE: To prepare acyclovir ophthalmic gel for the treatment of herpes simplex keratitis. Methods: Preparation and determination of acyclovir in the preparation content, in vitro test, stability test. Results: The preparation method was reasonable, the content of acyclovir was determined, and the interference of gel matrix could be ruled out. The stability test and in vitro release test showed that the preparation was stable in quality and sustained release. Through 60 cases of herpes simplex keratitis The clinical application, the total effective rate was 96.7%. Conclusion: The preparation of stable quality, no irritation to the eye, and the drug for a long time, is the ideal treatment for herpes simplex keratitis