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通过苯甲醛对壳聚糖2-NH2希夫碱化保护后,将壳聚糖C6位—OH与对甲苯磺酰氯反应形成对甲苯磺酰酯;然后用β-环糊精(-βCD)的单—NH2取代衍生物与之发生亲核取代反应,将环糊精固载到壳聚糖分子链上;最后,将得到的固载产物中的希夫碱脱保护后得到壳聚糖6-OH定位固载环糊精衍生物.采用FTIR,13C-NMR,元素分析,UV等表征手段对各步产物的结构进行了表征.紫外光谱法测定表明,-βCD在壳聚糖分子链C6位上的固载率达到了170.81μmol.g-1,远高于文献报道的其它方法制得的固载产物.采用XRD对各步产物的结晶性能进行了研究.
After the chitosan 2-NH2 Schiff basifically protected by benzaldehyde, the chitosan C6-OH is reacted with p-toluenesulfonyl chloride to form p-toluenesulfonyl ester; and then treated with β-cyclodextrin -NH2 substituted derivative with its nucleophilic substitution reaction, the cyclodextrin is immobilized on the molecular chain of chitosan; Finally, the resulting immobilized product was deprotected Schiff base obtained chitosan 6- OH was used to immobilize the cyclodextrin derivatives.The structures of the products were characterized by means of FTIR, 13C-NMR, elemental analysis and UV.The results of UV spectrophotometry showed that -CD in chitosan molecular chain C6 And the immobilization rate reached 170.81μmol.g-1, which is much higher than that of the immobilized product prepared by other methods reported in the literature.The crystallization behavior of each step was studied by XRD.