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本文应用改良八木法和放免法测定了142例糖尿病患者血浆 LPO、TXB_2、6—酮—前列腺素 F_1α水平,并将糖尿病患者按教血管病变的程度分为三组分析其与血浆 LPO、TXB+2、6—酮—PGF_1α的关系。结果表明有微血管病变糖尿病患者血浆 LPO、TXB_2/6—酮—PGF_1α比值升高,其升高程度与微血管病变轻重密切相关。血浆 LPO、T×B_2/6—酮—PGF+1α比值测定可作为早期诊断糖尿病微血管病变一项敏感指标。本文还观察了应用蛇毒抗栓酶、小剂量阿斯匹林、丹参治疗有微血管病变糖尿病患者治疗前后血浆LPO、TXB2/6—酮—PGF_1α比值的变化,结果表明血浆 LPO、TXB2/6—酮—PGF_1α比值测定可作为对糖尿病微血管病变疗效观察一项较敏感的实验室指标。
In this paper, we measured the levels of LPO, TXB2, 6-keto-PGF1α in 142 diabetic patients by improved Yamu method and radioimmunoassay, and divided them into three groups according to the degree of vascular disease. 2,6-keto-PGF-1α. The results showed that patients with microvascular lesions of plasma LPO, TXB_2 / 6-keto-PGF_1α ratio increased, the degree of increase is closely related with the severity of microvascular disease. Plasma LPO, T × B 2/6-keto-PGF + 1α ratio can be used as a sensitive indicator of early diagnosis of diabetic microangiopathy. This paper also observed the use of snake venom antithrombin, low-dose aspirin, Salvia miltiorrhiza treatment of patients with diabetes before and after treatment LPO, TXB2 / 6-keto-PGF_1α ratio changes, the results show that plasma LPO, TXB2 / 6- -PGF_1α ratio assay can be used as a sensitive laboratory test for the treatment of diabetic microangiopathy.