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目的 探讨动脉粥样硬化初期炎症反应机制和气血并治复方及方中理气药、活血药对其干预作用。方法 采用高脂应激造成大鼠高脂血症血瘀模型 ,观察各组大鼠脂质代谢、白介素 - 6、白介素 - 8和白细胞粘附活化分子表达率 (CD11b)的变化。结果 和模型组比较 ,全方组对TC、TG、TC HDL C、LDL C、IL 6、wCD11b和zCD11b有显著降低作用 ,理气药组对TC、TG、LDL C、IL 6、IL 8和wCD11b有显著降低作用 ,活血药组对TC、LDL C、IL 6和wCD11b有显著降低作用 (P <0 0 5和P <0 0 1)。结论 气血并治方可干预AS炎症反应 ,是抗AS的作用机制之一 ,方中理气药和活血药作用机制不尽相同 ,有协同作用。
Objective To investigate the initial inflammatory response mechanism of atherosclerosis and the intervention of qi and blood combined with prescriptions and Fangzhongzhong Qiqi and active blood drugs. Methods The hyperlipidemia model of blood stasis induced by hyperlipidemia in rats was used to observe the changes of lipid metabolism, interleukin-6, interleukin-8 and leukocyte adhesion activation molecule (CD11b) expression in each group. Results Compared with the model group, the Quanfang group had a significant reduction effect on TC, TG, TC HDL C, LDL C, IL 6, wCD11b, and zCD11b, and Qiqi medicine group on TC, TG, LDL C, IL 6, IL 8, and wCD11b. There was a significant decrease in the activity of TC, LDL C, IL 6 and wCD11b in the active blood group (P <0 05 and P <0 01). Conclusion Qixuebingzhi Prescription can intervene in the inflammatory response of AS, which is one of the mechanisms of anti-AS. The mechanism of action of Qizhong Qiqi and Activating Blood Drugs are not the same and have synergistic effects.