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目的探讨基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制因子-1(TIMP-1)在人睾丸精原细胞瘤组织中的表达及其与临床分期、预后的关系。方法采用免疫组织化学SP法检测33例人睾丸精原细胞瘤和11例正常睾丸组织中MMP-2、MMP-9、TIMP-1的表达,并与肿瘤的临床分期及预后进行比较。结果33例睾丸精原细胞瘤组织中MMP-2、MMP-9、TIMP-1的表达率分别为69.7%、75.8%、57.6%,表达率随肿瘤的临床分期升高而增加。MMPs/TIMPs比值大者死亡率高。结论MMP-2、MMP-9、TIMP-1在人睾丸精原细胞瘤的浸润转移过程中起重要作用,有可能成为估计预后的指标之一。
Objective To investigate the expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 Clinical stage, prognosis of the relationship. Methods Immunohistochemical SP method was used to detect the expression of MMP-2, MMP-9 and TIMP-1 in 33 cases of human testicular seminoma and 11 cases of normal testicular tissue. The clinical stage and prognosis were compared. Results The expression rates of MMP-2, MMP-9 and TIMP-1 in 33 cases of testicular seminoma were 69.7%, 75.8% and 57.6% respectively. The expression rates of MMP-2, MMP-9 and TIMP-1 increased with the clinical stage of tumors. The high ratio of MMPs / TIMPs has high mortality. Conclusion MMP-2, MMP-9 and TIMP-1 play an important role in the invasion and metastasis of human testicular seminoma and may be one of the prognostic indicators.