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近年大量研究结果显示,促红细胞生成素(EPO)是细胞因子超家族成员之一,具有多种非造血作用,如抗凋亡、抗氧化应激、促血管生成、调节炎症等,提示EPO具有潜在的保护作用。本文综述了EPO对神经细胞、心血管、肾脏及干细胞等细胞和器官的保护作用,并分析了其抗凋亡、抗炎症损害的可能机制;展望了EPO上述作用的临床应用价值,如EPO促血管新生效应,可能对心肌梗死后心室重构及心功能的恢复提供一定保护作用,EPO通过减少干细胞的凋亡发挥保护作用,提示可以利用EPO改善干细胞移植治疗的效果等。
In recent years, a large number of studies have shown that erythropoietin (EPO) is a member of the cytokine superfamily, with a variety of non-hematopoietic effects such as anti-apoptotic, anti-oxidative stress, proangiogenesis, regulating inflammation, suggesting that EPO has Potential protection. This review summarizes the protective effects of EPO on cells and organs such as nerve cells, cardiovascular, kidney and stem cells, and analyzes its possible mechanism of anti-apoptosis and anti-inflammatory damage. The clinical application value of EPO on these effects is prospected. For example, EPO The angiogenesis effect may provide a protective effect on ventricular remodeling and cardiac function recovery after myocardial infarction. EPO may play a protective role by reducing apoptosis of stem cells, suggesting that EPO may be used to improve the effect of stem cell transplantation treatment.