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绝经后妇女冠心病发病率较绝经前明显增加，绝经后予雌激素替代疗法，可减少冠心病发病率约５０％。表明女性的这种优势与雌激素的保护作用有关。雌激素的抗动脉粥样硬化作用已得到证实，但其确切机制仍在探索之中。血管内皮细胞损伤是动脉粥样硬化的主要致病因素之一。高水平
The prevalence of coronary heart disease in postmenopausal women was significantly higher than that before menopause, estrogen replacement therapy after menopause can reduce the incidence of coronary heart disease about 50%. This shows that this advantage of women and the protective effect of estrogen. The anti-atherosclerotic effect of estrogen has been confirmed, but its exact mechanism is still under investigation. Vascular endothelial cell injury is one of the main causative factors of atherosclerosis. High level