已知Sjogren’s综征合(下称Sjs)的重要特征之一是涎腺组织萎缩并伴有大量的淋巴细胞浸润。下唇唇腺活组织检查能全面地、确切地反映整个涎腺的情况,因此是诊断Sjs的一项重要依据。不仅如此,不少自身免疫病,如类风湿性关节炎(下称RA)、系统性红斑狼疮(下称SLE)、盘状红斑狼疮(下称DLE)、皮肌炎(下称DM)、白塞氏病(下称BD)等也可出现某些外分泌腺的障碍,下唇唇腺活检同样可呈现 One of the important features of Sjogren’s Syndrome (Sjs) is known to be atrophy of parotid glands with a large number of lymphocyte infiltration. Lower lip and labial gland biopsy can fully and exactly reflect the situation of the entire parotid gland, so it is an important basis for the diagnosis of Sjs. Not only that, many autoimmune diseases such as rheumatoid arthritis (hereinafter RA), systemic lupus erythematosus (SLE), discoid lupus erythematosus (DLE), dermatomyositis (DM), Some exocrine gland disorders may also occur in Behcet’s disease (hereinafter referred to as BD), and the lower lip gland biopsy can also be presented.