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IMB-86001是新型喹诺酮类第三代抗菌药物。小鼠和大鼠口服LD_(50)分别为4571mg/kg和>5000mg/kg,静注LD_(50)分别为345mg/kg和>300mg/kg。大鼠口服100、500和1000mg/kg/日,为期2个月,除500和1000mg/kg的大鼠尿中出现药物结晶和盲肠重量
IMB-86001 is the third generation quinolone antibacterial. The LD 50 of mice and rats were 4571 mg / kg and 5000 mg / kg, respectively. The LD 50 of mice and rats were 345 mg / kg and 300 mg / kg, respectively. Rats were orally dosed at 100, 500 and 1000 mg / kg / day for 2 months, with drug crystallization and cecal weight appearing in rat urine at 500 and 1000 mg / kg