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目的:研究醒脑静对大鼠脑缺血-再灌注损伤的保护作用及其机制。方法:60只大鼠随机分成6组,即假手术组、模型组、尼莫地平组及醒脑静低(3.33 mL/kg)、中(6.66 mL/kg)、高(10 mL/kg)剂量组,采用改良的线栓法制备大鼠局灶性脑缺血2 h/再灌注24 h损伤模型,醒脑静各组于缺血前30 min和缺血后2 h腹腔注射醒脑静注射液,假手术组和模型组给予等体积的NS,再灌注24 h,用改良的评分法对大鼠进行神经功能缺损评分后,用TTC染色法、伊文思兰法(EB)测定脑梗死范围及血脑屏障的损伤程度,分别测定血清白介素6、白介素1β(IL-6、IL-1β)的含量,脑组织中过氧化酶(MPO)和一氧化氮合酶(NOS)活性。结果:醒脑静能减少脑缺血-再灌注后脑梗死体积,减轻神经损伤症状,降低血清IL-6、IL-1β含量和脑组织中MPO、NOS活性。结论:醒脑静能减轻脑缺血-再灌注损伤,其机制可能与炎症介质释放有关。
Objective: To study the protective effect of xingnaojing on cerebral ischemia-reperfusion injury in rats and its mechanism. Methods: Sixty rats were randomly divided into 6 groups: sham operation group, model group, nimodipine group and Xingnaojing low (3.33 mL / kg), medium (6.66 mL / Dose group, the model of injury induced by focal cerebral ischemia 2 h / reperfusion 24 h was established by modified suture method. Each group of Xingnaojing injected intraperitoneally 30 min before ischemia and 2 h after ischemia received Xingnaojing The NS, NS, SHR group and model group were given equal volume of NS, then reperfusion for 24 h. The neurological deficit scores of rats were evaluated by modified score method. The infarction volume of cerebral infarction was determined by TTC staining and Evans blue method The levels of serum interleukin 6, interleukin 1β (IL-6, IL-1β) and the activity of peroxidase (MPO) and nitric oxide synthase (NOS) in brain tissue were measured. Results: Xingnaojing can reduce the volume of cerebral infarction after cerebral ischemia-reperfusion, reduce the symptoms of nerve injury, reduce the content of IL-6 and IL-1β in serum and the activity of MPO and NOS in brain tissue. Conclusion: Xingnaojing can reduce cerebral ischemia - reperfusion injury, the mechanism may be related to the release of inflammatory mediators.