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采用被动回避反应障碍动物模型，观察甲基黄酮醇胺（ＭＦＡ）对学习记忆的改善作用．结果，一次ｉｐＭＦＡ１０－２０ｍｇ·ｋｇ－１能明显对抗最大电休克致大鼠空间记忆损害．缩短其水迷宫实验中寻找水下平台时间，增加跨越水下平台相应位置的次数．在小鼠跳台实验中，ｉｐＭＦＡ５－１０ｍｇ·ｋｇ－１，每日１次，连续５ｄ，能逆转东莨菪碱（２ｍｇ·ｋｇ－１）所致记忆获得不良，改善亚硝酸钠（１２０ｍｇ·ｋｇ－１）引起的记忆巩固障碍及４０％乙醇（１０ｍＬ·ｋｇ－１）所致记忆再现障碍．延长小鼠台上停留时间，缩短电击后逃避潜伏期．同时，ｉｐＭＦＡ１０ｍｇ·ｋｇ－１，对小鼠的自主活动及痛阈无明显影响．提示，ＭＦＡ对电击和不同化学药品所致学习记忆损伤均具有显著改善作用
Animal model of passive avoidance reaction was used to observe the effect of methylflavone amine (MFA) on learning and memory. Results, ipMFA10-20mg · kg-1 can significantly antagonize the maximum electrical shock induced spatial memory impairment in rats. Shorten the water maze test to find the underwater platform time, increase the number of times across the corresponding position of the underwater platform. In mice jumping test, ipMFA5-10mg · kg-1, once a day, for 5 days, can reverse the scopolamine-induced memory deficits and improve the sodium nitrite (120mg · kg-1) Caused by memory consolidation disorders and 40% ethanol (10mL · kg-1) caused by memory impairment. Extend the stay time on the mouse stage, shorten the shock to escape the incubation period. At the same time, ipMFA10mg · kg-1, no significant effect on spontaneous activity and pain threshold in mice. It is suggested that MFA has a significant improvement on electric shock and learning and memory impairment caused by different chemicals