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目的探讨丁溴东莨菪碱联合双氯芬酸钠利多卡因治疗重度肾绞痛的临床效果。方法将我院急诊科收治并使用丁溴东莨菪碱联合双氯芬酸钠利多卡因治疗肾肾结石、输尿管结石引起的153例重度肾绞痛患者随机分为观察组76例和对照组77例,均使用足量有效的抗菌素,观察组给予丁溴东莨菪碱联合双氯芬酸钠利多卡因注射液治疗,对照组单用双氯芬酸钠利多卡因注射液治疗,首次给药1h后观察治疗效果,在3h后观察两组的疼痛复发情况并对疼痛复发患者进行二次给药,方法与第一次相同,继续观察疼痛缓解情况及不良反应。结果观察组治疗效果优于对照组,疼痛复发率低于对照组,差异有统计学意义(P<0.05)。结论外周抗胆碱药丁溴东莨菪碱与非甾体抗炎镇痛药双氯芬酸钠利多卡因联用对肾或输尿管结石引起的重度肾绞痛的治疗效果好、不良反应少,值得临床推广。
Objective To investigate the clinical effects of scopolamine-2-bromide combined with diclofenac sodium-lidocaine in the treatment of severe renal colic. Methods One hundred and fifty-three patients with severe renal colic caused by ureteral calculi treated with scopolamine and diclofenac sodium lidocaine in our emergency department were randomly divided into observation group (n = 76) and control group (n = 77) An effective amount of antibiotics, the observation group was treated with scopolamine and diclofenac sodium lidocaine injection, the control group was treated with diclofenac sodium and lidocaine alone, the first treatment was observed after 1h treatment, after 3h observed two groups Pain recurrence and secondary pain medication for patients relapse, the same way as the first time, continue to observe the pain relief and adverse reactions. Results The observation group was better than the control group, the recurrence rate of pain was lower than that of the control group, the difference was statistically significant (P <0.05). Conclusion Peripheral anticholinergic scopolamine and non-steroidal anti-inflammatory analgesic diclofenac sodium lidocaine combined with renal or ureteral stones caused by the treatment of severe renal colic have a good effect, less adverse reactions, is worth clinical promotion.