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从离体豚鼠右心室乳头肌，测定６种麻黄碱类药物的累积量－效曲线。ｄ－硫酸去甲伪麻黄碱，ｌ－盐酸麻黄碱，ｄ－盐酸麻黄碱和ｄ－盐酸伪麻黄碱对乳头肌的收缩作用呈浓度依赖性增强，ＰＤ２值分别为５７８，５５８，５２７和５２９。ｌ－盐酸甲基麻黄碱，氨基甲酰伪麻黄碱对乳头肌的收缩呈抑制作用，其ＩＣ５０分别为８７×１０－５ｍｏｌ／Ｌ和１．２６×１０－５ｍｏｌ／Ｌ。由等效法求得普萘洛尔和ｌ－盐酸甲基麻黄碱拮抗硫酸异丙肾上腺素反应的ｐＡ２值分别为７８６和４２９，ｌ－盐酸甲基麻黄碱拮抗－硫酸去甲伪黄碱反应的ｐＤ′２值为５５，结果提示麻黄碱类药物由于其侧链结构不同，其内在活性有量与质的差异。
Cumulative volume-response curves of 6 ephedrine drugs were determined from isolated right ventricular papillary muscles in guinea pigs. d-Pseudoephedrine sulfate, l-ephedrine hydrochloride, d-ephedrine hydrochloride and d-pseudoephedrine hydrochloride showed a dose-dependent increase in papillary muscle contraction with PD2 values of 578, 558 and 527 And 5 29. Methyl ephedrine hydrochloride and carbamoyl pseudoephedrine inhibited the papillary muscle contraction with IC50 of 87 × 10-5mol / L and 1.26 × 10-5mol / L, respectively. The pA2 values of propranolol and l-methyl-ephedrine hydrochloride against isoproterenol sulfate were determined by the equivalent method to be 786 and 429, respectively. Methyl ephedrine hydrochloride-antisulfate sulfate The pD’2 value of the reaction of caustic soda is 5 5, the results suggest that due to its different side chain structure, ephedrine drugs have inherent and quantitative differences in their intrinsic activities.