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肿瘤血管生成促进肿瘤的持续生长和转移。血管内皮生长因子(VEGF)是最特异和最重要的血管生成调节因子。通过与VEGF受体结合,VEGF刺激血管内皮细胞增殖和迁移,在新生血管过程中发挥关键作用。VEGF及其受体与结直肠癌肝转移的发生、发展、侵袭及预后有关,可能成为防治结直肠癌肝转移的有效靶点。本文就VEGF在结直肠癌肝转移中的研究进展予以综述。
Tumor angiogenesis promotes the continued growth and metastasis of tumors. Vascular endothelial growth factor (VEGF) is the most specific and important regulator of angiogenesis. By binding VEGF receptors, VEGF stimulates vascular endothelial cell proliferation and migration and plays a key role in neovascularization. VEGF and its receptor are associated with the occurrence, development, invasion and prognosis of colorectal cancer liver metastasis, which may become an effective target for prevention and treatment of liver metastasis of colorectal cancer. This article reviews the research progress of VEGF in liver metastasis of colorectal cancer.