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特发性直立性低血压(IOH)是一种原因不明的疾病,其特征为植物神经功能不全,直立时收缩期和舒张期血压水平降低≥20mmHg,而心率不加快。由此引起的低血压和脑灌注不足可导致晕厥。本文报告应用消炎痛(Indomethacin)治疗4例IOH患者和1例体位性低血压伴糖尿病患者的结果。这些患者的血浆肾素活性(PRA)降低,限盐和利尿剂刺激不能使之增高。醛固酮水平正常,用利尿剂治疗后升高。血浆容量、血浆多巴胺、β-羟化酶、尿儿茶酚胺、甲基肾上腺素和3-甲氧基-4-羟基杏仁酸
Idiopathic orthostatic hypotension (IOH) is an unexplained disease characterized by autonomic dysfunction, reduced systolic and diastolic blood pressure levels ≥ 20 mmHg in the vertical, and no accelerated heart rate. The resulting hypotension and cerebral hypoperfusion can lead to syncope. This article reports the results of four patients with IOH and one patient with orthostatic hypotension associated with diabetes treated with indomethacin. These patients have lower plasma renin activity (PRA), salt restriction and diuretic stimulation can not make it higher. Aldosterone levels were normal, elevated with diuretics. Plasma volume, plasma dopamine, β-hydroxylase, urinary catecholamines, methyl-epinephrine and 3-methoxy-4-hydroxy-mandelic acid