论文部分内容阅读
在1956年以前患滋养叶病预后都很差,而且发展甚快。1956年Li等报告的3例转移病例经过氨甲喋呤治疗后得到完全缓解。这是成功地应用化疗治疗实质性肿瘤的一个转折点。在最近20年里,滋养叶疾病有了更多的有效药物并在研究及治疗中积累了丰富的经验使得其预后更有所改善。有转移的患者持续缓解率可达90%,而病灶局限者实际上已达100%。以前对这种疾患的治疗通常都用子宫切除,现在可以说化疗不仅可以改善预后而且几乎可使所有希望保留生育机能的病人只用化疗。从很多报告大量病人治疗后成功的妊娠事例中说明这种方法是可靠的。一、滋养叶的生物学方面问题 Hertz提出妊娠滋养叶疾病是反映胎儿、绒毛的生物动力学过程。从形态学上讲良葡、恶葡及绒癌是一个疾病连续发展的不
Before 1956, the prognosis of trophoblastic disease were very poor, and the rapid development. In 1956 Li et al reported 3 cases of metastases after methotrexate treatment was completely relieved. This is a turning point for the successful application of chemotherapy for the treatment of solid tumors. In the last two decades, more effective drugs have been used to nourish leaf disease and a wealth of experience in research and treatment has led to an even better prognosis. Persistent patients with metastasis remission rate of up to 90%, while the lesion is actually up to 100%. Hysterectomy has usually been used to treat this condition, and now it can be said that chemotherapy not only improves the prognosis but also allows almost all patients who wish to retain their reproductive function with chemotherapy alone. This approach is reliable from many cases of pregnancy reported to be successful after a large number of patients have been treated. First, the biological aspects of nourishing leaves Hertz proposed nourish the disease of pregnancy is to reflect the fetus, villus biokinetic process. Morphologically speaking, good Portuguese, evil Portuguese and choriocarcinoma is a continuous development of the disease does not