论文部分内容阅读
１４只健康、成年羊。分为４组：Ｃ组（对照）、Ｓ组（Ⅱ级腱索切断）、Ｆ组（Ⅰ级腱索切断）和Ｐ组（乳头肌切断）。观察腱索或乳头肌切断前、后，血波动力学和心收缩性的变化。实验发现：（１）羊对照组测定血液动力学数值与人类相近。（２）腱索或乳头肌切断后，ＬＶＰ、ＴｈＢＰ、ＡｏＢＦ、＋ｄｐ／ｄｔｍａｘ、Ｖｍａｘ和ＣＲＨＬ－Ｌｓ数值均呈显著下降；ＬＡＰ和ＰＡＰ显著增加。组间比较有显著性差异（Ｐ＜０．０１）。－ｄｐ／ｄｔｍａｘ和ＣＭＬ－Ｌｄ指标，在Ｆ组和Ｐ组呈显著性下降，在Ｓ组有２％～３％值增加。结果提示：（１）选用羊作为研究人类急性二尖瓣口返流（ＡＭＲ）的发生及其机理是合适的。（２）腱索或乳头肌切断后，出现血液动力学和心肌收缩性的变化与切断引发ＡＭＲ和冠脉灌住减少，并进而造成心泵功能下降有关。
14 healthy, adult sheep. The rats were divided into 4 groups: group C (control), group S (grade Ⅱ chordae cut), group F (grade Ⅰ chordae cut) and group P (papillary muscle cut). Observed chordae or papillary muscle before and after cutting, hemodynamic and cardiac contractility changes. The experiment found: (1) Sheep control group measured hemodynamic values similar to humans. (2) The values of LVP, ThBP, AoBF, + dp / dtmax, Vmax and CRHL-Ls were significantly decreased after chiseling of tendons or papillary muscles; LAP and PAP were significantly increased. There was significant difference between groups (P <0.01). -dp / dtmax and CML-Ld indicators in the F group and P group showed a significant decline in the S group, 2% to 3% value increased. The results suggest that: (1) The selection of sheep as the study of human acute mitral valve regurgitation (AMR) and its mechanism is appropriate. (2) chyse or papillary muscle cut off, there hemodynamic and myocardial contractility changes and cut off trigger AMR and coronary perfusion decreased, and then cause decreased cardiac pump function.