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目的探讨小剂量米非司酮对子宫内膜异位症患者血清血管内皮生长因子(VEGF)和肝细胞生长因子(HGF)的影响。方法 126例子宫内膜异位症患者随机分为两组,观察组63例,采用米非司酮6.25 mg,1次/晚;对照组63例,采用米非司酮12.5 mg,1次/晚,两组共治疗3个月。测定治疗前后血清VEGF和HGF。结果治疗后对照组总有效率为90.5%,观察组总有效率为88.9%;两组总有效率比较,差异无统计学意义(χ2=1.62,P>0.05)。两组治疗后患者痛经VAS评分较治疗前均有明显降低(t=6.9216,6.0614,P<0.01),两组治疗后比较,差异无统计学意义(t=0.6218,P>0.05)。治疗后两组患者的血清VEGF和HGF较治疗前均有明显降低(t=5.9248,4.9928,P<0.01;t=3.0616,3.1734,P<0.05);两组治疗后血清VEGF和HGF比较,差异无统计学意义(t=0.3418,0.2926,P>0.05)。对照组治疗期间有13例发生不良反应,发生率为20.6%;观察组有8例发生不良反应,发生率为12.7%;观察组不良反应发生率明显少于对照组(χ2=5.72,P<0.05)。结论小剂量米非司酮可以明显降低子宫内膜异位症患者血清VEGF和HGF的表达,并且不良反应少。
Objective To investigate the effect of low dose mifepristone on serum vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with endometriosis. Methods 126 cases of endometriosis patients were randomly divided into two groups, the observation group of 63 cases, with mifepristone 6.25 mg, 1 / night; control group of 63 cases, the use of mifepristone 12.5 mg, 1 / Late, two groups were treated for 3 months. Determination of serum VEGF and HGF before and after treatment. Results After treatment, the total effective rate was 90.5% in the control group and 88.9% in the observation group. There was no significant difference between the two groups in total effective rate (χ2 = 1.62, P> 0.05). The VAS scores of dysmenorrhea in both groups were significantly lower than those before treatment (t = 6.9216,6.0614, P <0.01). There was no significant difference between the two groups after treatment (t = 0.6218, P> 0.05). After treatment, serum VEGF and HGF in both groups were significantly lower than before treatment (t = 5.9248, 4.9928, P <0.01; t = 3.0616,3.1734, P <0.05) Not statistically significant (t = 0.3418,0.2926, P> 0.05). In the control group, 13 cases had adverse reactions during the treatment period, the incidence rate was 20.6%. In the observation group, 8 cases had adverse reactions, the incidence rate was 12.7%. The incidence of adverse reactions in the observation group was significantly less than that in the control group (χ2 = 5.72, P < 0.05). Conclusion Low dose mifepristone can significantly reduce the expression of serum VEGF and HGF in patients with endometriosis, and less adverse reactions.