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钙拮抗剂药理作用的特点是选择性的阻断细胞膜慢通道的钙离子内流。近十余年来,新的钙拮抗剂不断问世,目前已达20余种。其中临床应用广泛且最具代表性的一组是异搏停、硝苯吡啶和硫氮(艹卓)酮。本文拟就这一组钙拮抗剂临床应用的选择问题做如下介绍。一、钙拮抗剂在心律失常治疗中的应用三种钙拮抗剂治疗室上性心动过速效果以异搏停为最佳,硫氮(艹卓)酮次之,硝苯吡啶无效。异搏停治疗室上速的经验比较成熟。90％以上病例可终止发作,与洋地黄相比具有起效快,半衰期短,不影响以后的电转复等特点。对于异位性非阵发性室上速,三种钙拮抗剂均无效;对于洋地
The pharmacological action of calcium antagonists is characterized by the selective blocking of calcium influx in the slow pathway of the cell membrane. Over the past decade, new calcium antagonists continue to come out, has reached more than 20 species. One of the most widely used clinical and the most representative group is verapamil, nifedipine and sulfur nitrogen (艹 Zhuo) ketone. This article intends to choose the clinical application of this group of calcium antagonists do the following introduction. First, the application of calcium antagonists in the treatment of arrhythmia Three kinds of calcium antagonists for the treatment of supraventricular tachycardia with verapamil stopped the best, followed by sulfur nitrogen (艹 Zhuo) ketone, nifedipine ineffective. Verapamil treatment of supraventricular tachycardia experience more mature. More than 90% of cases can terminate the attack, compared with digitalis has rapid onset, short half-life, does not affect the characteristics of the electrical conversion and later. For atopic non-paroxysmal supraventricular tachycardia, three kinds of calcium antagonists are ineffective; for the earth