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在脑内的促肾上腺皮质激素释放因子(CRF)可抑制副交感神经和提高交感神经活动。CRF 脑室内注射可抑制胃酸分泌,但对胃运动的影响未明。本文应用3~H 灌入大鼠胃中,(51)~Cr 分别注入十二指肠和大肠中作为胃肠转运的指标。结果发现,侧脑室注入 CRF 后,明显抑制胃排空和小肠转运,而促进大肠转运。胃排空的抑制效应可被神经节阻滞剂氯异吲哚铵、阿片对抗剂纳洛酮、肾上腺素能神经阻断剂溴苄铵阻断,但不被切断迷走神经所取消。氯异吲哚铵、纳洛酮、迷走神经切断术等可阻断小肠转运的抑制效应,但溴苄铵则否。氯异
Corticotropin releasing factor (CRF) in the brain inhibits parasympathetic nerves and increases sympathetic activity. CRF intracerebroventricular injection can inhibit gastric acid secretion, but the impact on gastric motility is unknown. In this paper, 3 ~ H perfusion rat stomach, (51) ~ Cr were injected into the duodenum and the intestine as an indicator of gastrointestinal transit. The results showed that lateral ventricle injection of CRF, significantly inhibited gastric emptying and intestinal transit, and promote colorectal transit. The inhibitory effect of gastric emptying could be blocked by the blockers of the ganglion, chloroisoindolium, the opioid antagonist naloxone, and the adrenergic blocker bromoxyni, but not by the vagus nerve. Chloroisoindolium, naloxone, vagotomy, etc. can block the inhibitory effect of intestinal transit, but whether brombenzyl ammonium. Chloro different