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目的:观察胃灵颗粒治疗胃癌前病变(PLGC)的临床疗效及其对胃癌前病变患者血清生长激素(GH)水平的影响,探讨胃灵颗粒对胃癌前病变的可能作用机理。方法:将60例胃癌前病变患者随机分为治疗组与对照组各30例,治疗组予胃灵颗粒,对照组予胃复春片治疗,对两组患者治疗前后的临床症状、胃镜病理和血清GH水平进行比较、分析及评价。结果:胃灵颗粒能显著改善胃癌前病变患者的临床症状,治疗3月后临床症状、综合疗效的总有效率分别为96.67%、90.00%,与胃复春组比较有统计学意义(P<0.05)。治疗前后血清GH测定结果显示,胃灵颗粒使患者血清GH水平显著升高(P<0.01),与对照组比较有统计学差异(P<0.05)。临床试验中两组均未见不良反应。结论:胃灵颗粒治疗胃癌前病变疗效肯定,能显著改善胃癌前病变患者的临床症状,提高患者血清GH水平。
Objective: To observe the clinical effect of Weiling granule on gastric precancerous lesions (PLGC) and its effect on serum growth hormone (GH) in patients with gastric precancerous lesions and to explore the possible mechanism of Weiling granule on gastric precancerous lesions. Methods: Sixty patients with gastric precancerous lesions were randomly divided into treatment group (30 cases) and control group (30 cases). The treatment group was treated with Weileiling Granules and the control group was treated with Weifuchun tablets. The clinical symptoms, Serum GH levels were compared, analyzed and evaluated. Results: Weiling granule can significantly improve the clinical symptoms of patients with gastric precancerous lesions. After 3 months of treatment, the total effective rate of clinical symptoms and comprehensive curative effects were 96.67% and 90.00%, respectively, which were significantly different from those of Wei Fu Chun group (P < 0.05). Serum GH levels before and after treatment showed that Wei-Ling granules significantly increased serum GH levels (P <0.01), compared with the control group (P <0.05). No clinical adverse reactions in both groups. Conclusion: Weiling granule treatment of gastric precancerous lesions positive effect, can significantly improve the clinical symptoms of gastric precancerous lesions and improve serum GH levels.