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目的对比观察强化胰岛素治疗与口服药治疗2型糖尿病合并慢性阻塞性肺病的临床效果。方法选择2016年6月至2017年5月我院收录诊治的2型糖尿病合并慢性阻塞性肺病患者62例作为本次对比治疗的研究对象,将其无规则随机平分为两个治疗组,即强化组与口服组,各31例。短期内给予强化组强化胰岛素治疗方案,而对口服组则采取口服降糖药物治疗方案。两组2型糖尿病合并慢性阻塞性肺病患者均持续治疗2周后,对比观察及研究其血糖控制效果以及胰岛功能恢复情况。结果强化组患者经强化胰岛素治疗2周后,其血糖的总有效控制率为96.77%(30/31),而口服组的为83.87%(26/31),对比研究其统计学意义具有鲜明的差异性(P<0.05);检测所得强化组患者治疗后的空腹状态下的血糖和糖化血红蛋白值以及餐后2h血糖值均明显降低,且显著低于口服组(P<0.05);并且强化组用药期间发生不良药物副反应率为3.23%(1/31),而口服组的为16.13%(5/31),对比检验P<0.05。结论强化胰岛素治疗相比于口服降糖药物治疗,更值得用于首诊2型糖尿病合并慢性阻塞性肺病患者,其于短期内即可产生非常显著的血糖控制效果,值得在临床实践治疗中给予官方推广。
Objective To compare the clinical effects of intensive insulin therapy and oral medication in the treatment of type 2 diabetes mellitus combined with chronic obstructive pulmonary disease. Methods Sixty-two patients with type 2 diabetes mellitus and chronic obstructive pulmonary disease (COPD) with diagnosis and treatment from June 2016 to May 2017 in our hospital were selected as the subjects of this comparative treatment and divided randomly into two treatment groups randomly Group and oral group, each 31 cases. In the short term, intensive treatment with intensive insulin was given, whereas in the oral group, oral hypoglycemic agents were used. Two groups of patients with type 2 diabetes mellitus and chronic obstructive pulmonary disease patients were treated for 2 weeks after the continuous observation and study of its blood glucose control effect and recovery of islet function. Results The total effective rate of glycemic control in intensive group was 96.77% (30/31) after two weeks of intensive insulin treatment, while it was 83.87% (26/31) in oral group, which was statistically significant compared with the control group (P <0.05). The fasting glucose and hemoglobin (HbA1c) values and postprandial blood glucose (2h) were significantly lower in the intensive group (P <0.05), which were significantly lower than those in the oral group (P <0.05) The rate of side effects of adverse drug reactions was 3.23% (1/31) during the course of treatment, compared with 16.13% (5/31) in the oral group, P <0.05. Conclusion Compared with oral hypoglycemic drugs, intensive insulin therapy is more suitable for the first diagnosis of type 2 diabetes patients with chronic obstructive pulmonary disease, which can produce very significant blood sugar control effect in a short period of time and is worth to be given in clinical practice treatment Official promotion.