本文报道了取代芳基溴化镁与α-溴代-D-四-O-乙酰葡萄糖的反应。4-甲氧基取代时影响不大,收率较好且以β碳苷为主要产物。2-甲氧基取代时反应产物复杂,分离出四个产物,均已鉴定。2,4-二甲氧基取代时,也有四个产物,但只对其α-及β-碳苷进行了分离鉴定。2-苄氧基取代及2,6-二苄氧基取代时则因位阻较大,C_1~’位亲核取代反应难以发生。 This paper reports the reaction of substituted arylmagnesium bromide with α-bromo-D-tetra-O-acetylglucose. 4-methoxy substitution has little effect, good yield and β-carbon glycosides as the main product. The reaction product was complex when 2-methoxy was substituted, and four products were isolated and identified. When 2,4-dimethoxy was substituted, there were also four products, but only the α- and β-carbon glycosides were isolated and identified. When the substitution of 2-benzyloxy and 2,6-dibenzyloxy, the steric hindrance is larger, nucleophilic substitution reaction of C 1 ~ ’is difficult to occur.