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目的:对广西莪术(Curcuma kwangsiensis)的根茎进行化学成分研究。方法:运用硅胶、Sephadex LH-20柱色谱、ODS柱色谱和制备HPLC等分离手段进行化学成分的分离纯化,根据其波谱数据鉴定其结构。结果:从广西莪术中分离得到 7个化合物,分别鉴定为:[4-(1′-hydroxy-1′-methylethyl) benzoate-1′-O-β-D-glucopyranoside](1),[4-(1′-hydroxy-1′-methylethyl) ben-zoic acid-1′-O-β-D-glucopyranoside](2),2, 3,5-trihydroxy-1-(3-methoxy-4-hydroxyphenyl)-7-(3,5-dimethoxy-4-hydroxyphenyl) hep-tane(3) and 2,3, 5-trihydroxy-1-(4-hydroxyphenyl)-7-(3,5-dimethoxy-4-hydroxyphenyl)heptane(4),以及 1,5-epoxy-3α-hydroxy- 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxy)heptane(5),(3R′,5S′)-3,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl) heptane(6),2,4,6-trihydroxyacetophenone-2,4-di-O-β-D-glucopyranoside(7)。结论:化合物1-4为新化合物,化合物3-7对脂多糖所致巨噬细胞产生一氧化氮表现出强的抑制活性。
Objective: To study the chemical constituents of Curcuma kwangsiensis rhizome. Methods: The constituents were separated and purified by silica gel, Sephadex LH-20 column chromatography, ODS column chromatography and preparative HPLC. Their structures were identified by their spectral data. Results: Seven compounds were isolated from Curcuma anguillarum and identified as [4- (1’-hydroxy-1’-methylethyl) benzoate-1’-O-β-D-glucopyranoside] (2’-hydroxy-1’-methylethyl) ben-zoic acid-1’-O-β-D-glucopyranoside] (3,5-dimethoxy-4-hydroxyphenyl) hep-tane (3) and 2,3,5-trihydroxy- heptane (4), and 1,5-epoxy-3α-hydroxy- 1- (3,4- dihydroxy- 5-methoxyphenyl) -7- (3,4- dihydroxy) heptane (5), (3R ’ ) -3,5-dihydroxy-1- (4-hydroxy-3-methoxyphenyl) -7- (3,4- dihydroxyphenyl) heptane (6), 2,4,6-trihydroxyacetophenone- β-D-glucopyranoside (7). Conclusion: Compound 1-4 is a new compound, and compound 3-7 shows strong inhibitory activity on lipopolysaccharide-induced nitric oxide production by macrophages.