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目的：探讨肿瘤坏死因子-α(TNF-α)、可溶性肿瘤坏死因子受体(STNFR)与宫颈癌发生、发展及淋巴转移的关系。方法：用双抗体夹心ELISA法检测宫颈癌42例和宫颈上皮内瘤变(CIN)14例血清TNF-α和STNFRⅠ、STNFRⅡ，并与正常34例对照。结果：宫颈癌患者血清TNF-α、STNFRⅠ、STNFRⅡ以及CIN患者STNFRⅠ、STNFRⅡ水平较正常对照组明显增高(P＜001)；Ⅱ期宫颈癌患者血清STNFRⅠ、STNFRⅡ水平与Ⅰ期患者相比，差异无显著性；宫颈癌有淋巴转移组患者血清STNFRⅠ、STNFRⅡ水平明显高于无淋巴转移组(P＜00001)；经相关分析STNFRⅠ、STNFRⅡ在宫颈癌、宫颈癌淋巴转移组、宫颈癌无淋巴转移组及正常对照组均呈正相关关系，仅CIN组无明显正相关。结论：TNF-α、STNFR与宫颈癌的发生发展有关，STNFR可能是判断宫颈癌是否发生淋巴转移较好的监测指标，对判断预后有重要价值。
Objective: To investigate the relationship between tumor necrosis factor-α (TNF-α) and soluble tumor necrosis factor receptor (STNFR) and the occurrence, development and lymph node metastasis of cervical cancer. Methods: Twenty-four cases of cervical cancer and 14 cases of cervical intraepithelial neoplasia (CIN) were tested for TNF-α, STNFRⅠ and STNFRⅡ by double antibody sandwich ELISA. Results: The serum levels of TNF-α, STNFRⅠ, STNFRⅡ and CIN in patients with cervical cancer were significantly higher than those in normal controls (P <001). The serum levels of STNFRⅠ and STNFRⅡ in patients with stage Ⅱ cervical cancer were significantly higher than those in patients with stage Ⅰ , The difference was not statistically significant. The serum levels of STNFRⅠand STNFRⅡ in patients with cervical lymph node metastasis were significantly higher than those without lymph node metastasis (P <00001). The correlation between STNFRⅠand STNFRⅡin cervical cancer, cervical lymph node metastasis, No lymph node metastasis and normal control group were positively correlated, only CIN group had no significant positive correlation. CONCLUSIONS: TNF-αand STNFR are correlated with the occurrence and development of cervical cancer. STNFR may be a good indicator to judge whether cervical cancer is lymphatic metastasis, which is of great value in judging prognosis.