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目的:探讨应用复方丹参注射液和硝酸甘油治疗早发型重度子痫前期的疗效差异,旨在为规范早发型重度子痫前期的治疗方案提供依据。方法:将我院妇产科2009年1月～2012年1月收治的108例早发型重度子痫前期患者随机分成两组,即对照和实验组。对照组患者在常规治疗的基础上加用复方丹参注射液进行治疗,实验组患者在常规治疗的基础上加用硝酸甘油进行治疗。治疗结束后,比较两组患者及其新生儿出现并发症的情况。结果:①两组患者的新生儿出现窘迫、窒息和死亡的情况具有显著性差异(x2=4.960,P<0.05;x2=5.939,P<0.05;x2=5.243,P<0.05);②两组患者出现蛋白尿、胎盘早剥和HELLP综合征的情况具有显著性差异(x2=6.353,P<0.05;x2=6.684,P<0.05;x2=3.893,P<0.05);③两组患者发生心力衰竭和视网膜病变的情况无显著性差异(x2=0.911,P>0.05;x2=2.824,P>0.05)。结论:与复方丹参注射液相比,硝酸甘油在降低孕产妇及新生儿并发症的发生率、改善母婴预后等方面具有突出的疗效,是一种值得在临床上推广和应用的治疗早发型重度子痫前期的药物。
Objective: To explore the application of compound Salvia miltiorrhiza injection and nitroglycerin in the treatment of early-onset severe preeclampsia, and to provide basis for the treatment of early-onset severe preeclampsia. Methods: 108 patients with early-onset severe preeclampsia who were admitted to our hospital from January 2009 to January 2012 were randomly divided into two groups, control group and experimental group. Patients in the control group were treated with compound Danshen injection on the basis of routine treatment. Patients in the experimental group were treated with nitroglycerin on the basis of routine treatment. After treatment, comparisons were made between two groups of patients and their newborns. Results ① There was significant difference in neonatal distress, asphyxia and death between two groups (χ2 = 4.960, P <0.05; x2 = 5.939, P <0.05; Patients with proteinuria, placental abruption and HELLP syndrome had significant differences (x2 = 6.353, P <0.05; x2 = 6.684, P <0.05; x2 = 3.893, P < There was no significant difference between failure and retinopathy (x2 = 0.911, P> 0.05; x2 = 2.824, P> 0.05). Conclusion: Compared with compound Danshen injection, nitroglycerin has outstanding curative effect in reducing the incidence of maternal and newborn complications and improving maternal and infant prognosis, which is worthy of clinical promotion and application in the treatment of early-onset type Severe preeclampsia drug.