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目的：观察右美托咪定对全麻下食管癌根治术后苏醒期患者的影响。方法选择60例食管癌根治术患者，年龄55～78岁，体重48～75 kg，ASAII级，随机分成右美托咪定组（Y组）和对照组（D组）各30例，在手术结束前30 min分别给予右美托咪定0．5？g/（kg？h）和等体积的生理盐水30 min，观察围拔管期（拔管前10min、拔管前5 min、拔管即刻、拔管后5 min、拔管后10 min）血压、心率、血氧饱和度、苏醒时间、拔管时间、VAS评分及术后不良反应发生情况如术后烦躁、呼吸抑制、寒战。结果 Y组在拔管期心率、血压明显低于D组（P＜0．05）。Y组VAS评分＞5分和术后烦躁患者少于D组（P＜0．05），血氧饱和度、苏醒时间，拔管时间和寒战两组比较差异无统计学意义，两组患者均未出现呼吸抑制。结论右美托咪定应用于全身麻醉下食管癌根治术患者，提供有效的镇静、镇痛，降低后苏醒期的血流动力学波动幅度，术中血流动力学比较平稳，不影响苏醒期拔管时间，值得临床推广应用。“,”Objective To observe the ef ect of dexmedetomidine on the recovery period in patients with esophageal cancer after radical surgery under general anesthesia.Methods 60 pa-tients with esophageal cancer,aged 55 ~78 years of age,body weight 48 ~75 kg,ASAII grade,were randomly divided into dexmedetomidine group (Y group)and control group (D group) 30 cases,in operation before the end of the 30 min were administered dexmedetomidine (0.5 ?g /kg ?h)saline and an equal volume of 30 min,observe the extubation (before extubation 10min,before extubation 5 min,10 min after extubation time,extubation 5 min,after extubation)blood pressure,heart rate,oxygen saturation,recovery time,extubation adverse reaction time, VAS score and postoperative conditions such as postoperative irritability,respiratory inhibition,chil s.Results in Y group,heart rate,blood pressure in tube drawing were lower than those of group D (P<0.05).Less than D group Y group more than 5 fidgety patients VAS score and postoperative (P<0.05),oxygen saturation,no significant recovery time,extubation time and chil s dif erence between the two groups,two groups of patients without respiratory depression.Conclusion dexmedetomidine used in general anesthesia in patients undergoing resection of esopha-geal cancer,and provide ef ective sedation,analgesia,reduce the recovery period after hemodynamic fluctuations,intraoperative hemodynamics more stable,does not af ect the emergence time of extubation,worthy of clinical application.