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目的:通过对一株拟青霉菌(Paecilomyces sp.)的研究获得活性次生代谢产物。方法:利用固体大米培养基对该株拟青霉菌(Paecilomyces sp.)进行发酵培养,利用硅胶、凝胶柱层析法以及高效液相色谱等技术对该株真菌的次生代谢产物进行研究。通过质谱和核磁共振等现代波谱分析方法对其结构进行了鉴定。结果:共分离得到4个次生代谢产物,分别为:Cerebroside C(1)、Cerebroside D(2)、2-Hydroxybenzyl alcohol(3)、2-(4-Hydroxyphenyl)ethanol(4)。结论:以上4个化合物均为首次从该株真菌中分离得到。
Objective: To obtain active secondary metabolites through the study of a Paecilomyces sp. Methods: Fermentation of Paecilomyces sp. Was carried out using solid rice medium. The secondary metabolites of the fungus were studied by using silica gel, gel column chromatography and high performance liquid chromatography. Its structure was identified by modern spectroscopic methods such as mass spectrometry and nuclear magnetic resonance. Results: Four secondary metabolites were isolated and identified as Cerebroside C (1), Cerebroside D (2), 2-Hydroxybenzyl alcohol (3) and 2- (4-Hydroxyphenyl) ethanol (4). Conclusion: The above four compounds were isolated from the fungus for the first time.