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头孢菌素Ⅰ(Cephalothin)和青霉素侧链经化学结构改造后产生了一系列β-内酰胺类抗生素,它们已用于临床。新近发现改变母核本身的结构将产生具杰出抗菌特点的新抗生素,它们的抗菌作用大多很强,抗菌谱广,对绿脓杆菌也有效。其高效和低毒性优于氨基糖苷类抗生素。本文采用Denley细菌接种器以琼脂稀释法测定和比较一组抗生素(大多为新品种)的抗菌作用。试验菌为肠杆菌科600支菌株,
Cephalothin and penicillin side chains have been chemically modified to produce a series of beta-lactam antibiotics that have been used clinically. Recently found that changing the structure of the mother’s own nucleus will produce a new antibiotic with outstanding antibacterial properties, their antibacterial effect is mostly strong, broad antibacterial spectrum, effective against Pseudomonas aeruginosa. Its high efficiency and low toxicity than aminoglycoside antibiotics. In this paper, the Denley bacteria inoculator was used to determine and compare the antibacterial effect of a group of antibiotics (mostly new varieties) by agar dilution method. Test bacteria Enterobacteriaceae 600 strains,