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微小RNA(microRNA,miRNA)是一类内源性非编码小RNA,可调控不同基因的表达,从而改变细胞和生物体的表型。微小RNA-218(MicroRNA-218,miR-218)的异常表达可导致细胞的增殖、分化、凋亡异常,与肿瘤的发生发展及预后密切相关。本文简述了miR-218与女性生殖系统肿瘤、消化道肿瘤、颅内肿瘤、呼吸道肿瘤、泌尿生殖系肿瘤之间的关系,拟出miR-218可能的调控机制,有助于为肿瘤的诊断和治疗提供新的靶点。
MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs that regulate the expression of different genes and thereby alter the phenotype of cells and organisms. The abnormal expression of microRNA-218 (MicroRNA-218, miR-218) can lead to abnormal proliferation, differentiation and apoptosis of cells, which is closely related to tumorigenesis and prognosis. This article describes the relationship between miR-218 and female reproductive system tumors, gastrointestinal tumors, intracranial tumors, respiratory tumors, genitourinary tumors, and proposes a possible regulatory mechanism of miR-218, which is helpful for the diagnosis of tumors And treatment provides a new target.