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目的探讨尼可地尔治疗不稳定型心绞痛的临床治疗效果。方法选择某院不稳定型心绞痛患者90例,随机分为观察组和对照组。对照组患者给予双重抗血小板、硝酸酯类药物、β受体阻滞剂、ACEI、低分子肝素以及他汀类药物等。观察组在对照组用药基础上给予尼可地尔5mg,3次/日,连续治疗2周。观察两组患者在治疗期间心绞痛发作情况,同时对心电图定期检测,是否有头痛等不良反应。结果观察组总有效率为93.3%,对照组总有效率为75.6%,两组总有效率比较,差异有统计学意义(P﹤0.05)。结论尼可地尔能够显著改善不稳定型心绞痛患者临床症状和体征,临床治疗效果显著。
Objective To investigate the clinical effect of nicorandil in the treatment of unstable angina pectoris. Methods 90 patients with unstable angina in a hospital were randomly divided into observation group and control group. Control group patients given dual antiplatelet, nitrates, β blockers, ACEI, low molecular weight heparin and statins. The observation group was given nicorandil 5 mg on the basis of the control group, 3 times a day for 2 weeks. During the treatment, angina pectoris was observed in both groups. At the same time, ECGs were regularly tested for headache and other adverse reactions. Results The total effective rate was 93.3% in the observation group and 75.6% in the control group. The total effective rate in the two groups was statistically significant (P <0.05). Conclusion Nicorandil can significantly improve the clinical symptoms and signs of patients with unstable angina, clinical treatment effect is significant.