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目的了解新疆志贺氏菌菌型及对23种抗菌药物的耐药情况,为痢疾的防治和临床用药提供科学依据。方法对2006─2015年新疆各肠道传染病监测点现场分离的2 907株志贺氏菌进行系统分型鉴定,并挑选部分菌株(2 215株)采用琼脂扩散法(K-B法)检测对23种抗菌药物的敏感性。结果 2 907株受试菌菌群分布以福氏志贺氏菌居优势、占91.88%,其次为宋内志贺氏菌(6.71%)、痢疾志贺氏菌(0.93%)和鲍氏志贺氏菌(0.48%);占优势的福氏志贺氏菌亚型分布除2014年F2b*(42.86%)为优势外,其他年份均以F2a为主,各监测点无明显差异;2 215株菌株对23种抗菌药均有不同程度耐药,耐药率居前3位的依次为青霉素(94.36%)、链霉素(89.71%)和强力霉素(87.81%),没有100.00%敏感的抗菌药物,并且耐受6种及以上抗菌药物的菌株比例较高为57.34%。结论新疆志贺氏菌以福氏属中的F2a为优势株,细菌性痢疾是新疆常见而多发的肠道传染病之一,对常用抗菌药物耐药情况较为严重,因此正确选用抗菌药物是有效治疗痢疾的关键。
Objective To understand the pathogenicity of Shigella spp. In Xinjiang and its resistance to 23 kinds of antibiotics to provide a scientific basis for the prevention and treatment of dysentery. Methods A total of 2 907 Shigella isolates isolated from the monitoring stations of intestinal infectious diseases in Xinjiang from 2006 to 2015 were systematically identified. Some strains (2 215 strains) were screened by agar diffusion method (KB method) Antibacterial drug sensitivity. Results The distribution of 2 907 strains of bacteria was dominant in Shigella flexneri, accounting for 91.88%, followed by Shigella sonnei (6.71%), Shigella dysenteriae (0.93%), In addition to F2b * (42.86%) in 2014, the predominant subtype of Shigella flexneri distributed in all the other years with F2a as the dominant species, with no significant difference among the monitoring sites; 2 Strains were resistant to 23 kinds of antibacterials in varying degrees. The top three strains were penicillin (94.36%), streptomycin (89.71%) and doxycycline (87.81%), with no 100.00% sensitivity Of the antibacterial drugs, and resistant to 6 or more antibacterial drugs, a higher proportion of strains was 57.34%. Conclusions Xinjiang Shigella is the dominant strain of F2a in the genus Fufang. Bacillary dysentery is one of the most common and frequent intestinal infections in Xinjiang. It is more resistant to the commonly used antibiotics, so it is effective to choose the correct antibiotics The key to treating diarrhea.