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目的 探索栝蒌薤白汤防治肺纤维化的作用机理。方法 大鼠气管滴入平阳霉素建立肺纤维化模型 ,用药组按 2 0g/kg体重灌胃栝蒌薤白汤 ,每日 1次 ,2 8d后 ,检测各组大鼠肺组织中去甲肾上腺素 (NE)、多巴胺 (DA)、5 -羟色胺 (5 HT)含量及支气管肺泡灌洗液 (BALF)中炎症细胞总数 ,进行组间比较。结果 模型组NE、DA、5 HT含量及BALF中细胞总数均显著高于正常对照组 ,栝蒌薤白汤组NE、DA含量及BALF中细胞总数均显著低于模型组。结论 栝蒌薤白汤能抑制肺纤维化模型肺组织中NE、DA含量的增高 ,降低BALF中的炎症细胞数量
Objective To explore the mechanism of Qibai Decoction in preventing and treating pulmonary fibrosis. Methods Pulmonary fibrosis model was established by instillation of Pingyangmycin into the rat’s trachea. The drug group was treated with 20% g/kg body weight and was administered with Qibai Decoction once a day for 28 days. The levels of ER (NE), dopamine (DA), serotonin (5 HT), and inflammatory cells in bronchoalveolar lavage fluid (BALF) were compared between groups. Results The contents of NE, DA and 5 HT in the model group and the total number of cells in the BALF were significantly higher than those in the normal control group. The contents of NE and DA in the Qibai Decoction group and the total number of cells in the BALF were significantly lower than those in the model group. Conclusion Qibai Decoction can inhibit the increase of NE and DA in pulmonary fibrosis model and reduce the number of inflammatory cells in BALF.