目的观察来氟米特联合甲氨蝶呤治疗多发性肌炎对患者肌力的影响。方法 94例多发性肌炎患者,按照单双号法分成联合组和对照组,各47例。对两组患者均实施基础治疗,在此基础上给予对照组患者甲氨蝶呤治疗,给予联合组患者来氟米特联合甲氨蝶呤治疗,比较两组治疗效果。结果治疗前,两组患者的肌力比较差异无统计学意义(P>0.05);治疗4周后,联合组患者的肌力达3级率为72.3%,明显高于对照组的51.1%(P<0.05);治疗8周后,联合组患者的肌力达3级率为85.1%,显著高于对照组患者的59.6%(P<0.01)。结论来氟米特联合甲氨蝶呤治疗多发性肌炎可有效提升患者肌力,改善患者临床治疗效果。 Objective To observe the effect of leflunomide and methotrexate on the muscle strength of patients with polymyositis. Methods 94 patients with polymyositis were divided into combined group and control group according to single and double number method, 47 cases in each. The two groups of patients were treated with basic treatment, on the basis of the control group patients given methotrexate treatment, the combination group leflunomide combined with methotrexate treatment, the two groups were compared. Results Before treatment, there was no significant difference between the two groups in muscle strength (P> 0.05). After 4 weeks of treatment, the third grade of the third group was 72.3%, which was significantly higher than that of the control group (51.1% P <0.05). After 8 weeks of treatment, the 3rd grade of muscle strength in combined group was 85.1%, which was significantly higher than that in control group (59.6%, P <0.01). Conclusion Leflunomide combined with methotrexate in the treatment of polymyositis can effectively improve the patient’s muscle strength and improve the clinical effect of treatment.