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目的:分析基本药物在基层医疗机构发生药品不良反应(ADR)情况,促进临床合理用药。方法:回顾性分析百色市2011年涉及基本药物ADR报告。结果:涉及国家基本药物的ADR报告有1 097份,占总报告数(1 748份)的62.76%,其主要来源于医疗机构,占98.18%;≤10岁儿童ADR比例最高,占17.68%;静脉给药方式是引发ADR的重要途径,占82.68%;以抗微生物药品最多,占63.17%;最常见的临床表现为皮肤及其附件损害,占40.96%。结论:应重视基本药物ADR报告和监测工作,以减少或避免ADR的发生,保障患者用药安全。
Objective: To analyze the adverse drug reaction (ADR) of essential drugs in primary medical institutions and to promote the rational use of drugs. Methods: A retrospective analysis of Baise City in 2011 related to essential medicines ADR report. Results: There were 1 097 ADR cases, accounting for 62.76% of the total reported cases (1 748 cases), mainly from medical institutions, accounting for 98.18% of all ADR cases. The highest ADR was found in children ≤10 years old, accounting for 17.68%. Intravenous administration is an important way to trigger ADR, accounting for 82.68%; with antimicrobial drugs up to 63.17%; the most common clinical manifestations of damage to the skin and its accessories, accounting for 40.96%. Conclusion: The ADR report and monitoring of essential drugs should be emphasized in order to reduce or avoid the occurrence of ADR and ensure the safety of patients.