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[目的]探讨非典型脑膜瘤(AM)的临床病理学特点及预后相关因素。[方法]回顾性分析54例AM的临床病理资料,并根据随访结果将患者分成死亡复发组和无死亡复发组,对两组患者的8项临床病理学指标进行统计分析。[结果]54例AM患者中位年龄58岁,次全切除8例。30例肿瘤最大径≥5cm,17例见肿瘤侵犯脑组织,13例核分裂≥4/10HPF,32例可见肿瘤组织自发性坏死,26例肿瘤细胞有明显核仁,Ki-67指数平均为7.04%。36例无复发存活,7例复发,11例死亡。上述8项指标在两组之间的差异均具有统计学意义(P<0.05)。[结论]肿瘤最大径≥5cm、未被完全切除、肿瘤侵犯脑组织、有自发性坏死、瘤细胞有显著核仁、核分裂≥4/10HPF、Ki-67指数≥7%是非典型脑膜瘤患者复发或死亡的危险因素。
[Objective] To investigate the clinicopathological features and prognostic factors of atypical meningioma (AM). [Methods] The clinical and pathological data of 54 cases of AM were retrospectively analyzed. According to the follow-up results, the patients were divided into death recurrence group and non-death recurrence group. Eight clinical pathological indexes of the two groups were statistically analyzed. [Result] The median age of 54 patients with AM was 58 years old and subtotally resected in 8 cases. The diameter of the tumor in most cases was ≥5cm, the tumor invaded the brain in 17 cases, the rate of nuclear fission in the 13 cases was ≥4 / 10HPF, spontaneous necrosis in 32 cases, obvious nucleolus in 26 cases, Ki-67 index was 7.04% . 36 had no recurrence, 7 had recurrent, and 11 had died. The above eight indicators in the two groups were statistically significant differences (P <0.05). [Conclusion] The maximal diameter of tumor is more than or equal to 5cm, not completely resected. The tumor invades the brain and has spontaneous necrosis. The tumor cells have significant nucleoli and mitotic index≥4 / 10HPF. The Ki-67 index≥7% is the recurrence of atypical meningiomas Or risk of death.