血小板功能障碍可分为遗传性及获得性两类。现将典型遗传性血小板功能障碍性疾病概述如下: 一、血小板无力症先天性血小板无力症于1918年Glanzman首先报道,Nurden和Caen在1974年证实为分子病,患者的出血倾向和血小板功能异常是由于血小板膜内糖蛋白Ⅱ_b和Ⅲ_a的缺损所致。本病是一种常染色体隐性遗传两性均可发病及遗传。多见于近亲婚配,常有家族出血史。自幼 Platelet dysfunction can be divided into two types of genetic and acquired. Now typical hereditary platelet dysfunction disease is summarized as follows: First, platelet atherosclerosis Congenital platelet atherosclerosis Glanzman first reported in 1918, Nurden and Caen in 1974 proved to be molecular disease, the patient’s bleeding tendency and abnormal platelet function is Due to platelet membrane glycoproteins Ⅱ_b and Ⅲ_a defects caused. The disease is an autosomal recessive genetic both can be disease and heredity. More common in marriage, often have a family history of bleeding. Since childhood