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对１０６例不同疾病新生儿和４０例正常新生儿用萘酚ＡＳ—ＭＸ法测定白细胞硷性磷酸酶活性（ＬＡＰＡ）。结果：①细菌感染组治疗前ＬＡＰＡ明显高于对照组、非感染组和病毒组（Ｐ均＜０．０１）；病毒感染组ＬＡＰＡ明显低于对照组（Ｐ＜０．０５）。②细菌感染组治疗后ＬＡＰＡ下降，与治疗前比较有非常显著性差异（Ｐ＜０．０１）；病毒感染组治疗后ＬＡＰＡ增高，明显高于治疗前（Ｐ＜０．０１）；非感染组治疗前后无差异（Ｐ＞０．０５）。③１０例严重细菌感染的濒死患儿入院时ＬＡＰＡ明显低于一般感染组和对照组（Ｐ均＜０．０１），治疗后明显高于治疗前（Ｐ＜０．０５）。提示ＬＡＰＡ不但是诊断新生儿感染性疾病有意义的检测指标，而且对细菌和病毒性疾病的鉴别及判断疗效和估计预后有重要的临床价值。
White blood cell alkaline phosphatase activity (LAPA) was measured by Naphthol AS-MX method in 106 newborns with different diseases and 40 normal newborns. Results: (1) LAPA in bacterial infection group was significantly higher than that in control group, non-infected group and virus group (P <0.01). LAPA in virus-infected group was significantly lower than that in control group (P <0.05). ② The LAPA in bacterial infection group decreased significantly compared with that before treatment (P <0.01). The LAPA in viral infection group was significantly higher than that before treatment (P <0.01) No difference between before and after treatment (P> 0.05). (3) The incidence of LAPA in 10 cases of serious bacterial infection was significantly lower than that of the general infection group and the control group (P <0.01), and was significantly higher than that before treatment (P <0.05). The results suggest that LAPA is not only a useful diagnostic indicator for the diagnosis of neonatal infectious diseases, but also has important clinical value in distinguishing and judging bacterial and viral diseases and estimating prognosis.