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诺沃克城某学校爆发非细菌性胃肠炎报道至今已21年,电镜发现病人粪样中致病因子也已18年。尽管人们都想了解这一因子和其他形态上难以区分的颗粒,但20多年来的研究进展却相当缓慢。究其原因主要由于临床标本中病毒纯化困难,又不能体外培养,而且缺乏分类学的基本资料。根据其大小、浮密度、主要多肽及有限的血清学资料,推测诺沃克因子属嵌杯样病毒科。在英国一般称这些病毒为小圆形病毒(SRSVs),但未得到国际公认。
Non-bacterial gastroenteritis has been reported in a school in Norwalk City for 21 years and electron microscopy has also found that the virulence factor in fecal samples of patients has been 18 years. Although people all want to know this factor and other morphologically indistinguishable particles, the progress made in more than two decades has been rather slow. The reason is mainly due to the difficulty of virus purification in clinical specimens, but also can not be cultured in vitro, and the lack of taxonomy of the basic information. According to its size, floating density, the main polypeptide and limited serological data, it is speculated that Norwalk factor is a caecum-like virus family. These viruses are commonly referred to in the UK as roundish virus (SRSVs), but have not been internationally recognized.