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目的分析内皮素系统与肿瘤发生发展的关系,为内皮素受体成为抗肿瘤药物新的作用靶点提供依据,同时为抗肿瘤药物研究提供新思路。方法检索2000—2010年国内外医学期刊中内皮素系统与肿瘤发生发展及内皮素受体拮抗剂与肿瘤治疗的资料,综述内皮素及其受体拮抗剂与肿瘤的关系。结果内皮素受体是抗肿瘤药物新的作用靶点。结论内皮素受体拮抗剂将成为肿瘤治疗中的新型药物。
Objective To analyze the relationship between endothelin system and tumorigenesis and to provide basis for endothelin receptor to become a new target of antitumor drugs and to provide new ideas for antitumor drug research. Methods The data of endothelin system and tumor development and the treatment of endothelin receptor antagonist and tumor from 2000 to 2010 in domestic and foreign medical journals were reviewed. The relationship between endothelin and its receptor antagonist and tumor was reviewed. Results Endothelin receptor is a new target of anti-tumor drugs. Conclusion Endothelin receptor antagonist will become a new drug in the treatment of cancer.